Tadalafil works by relaxing the muscles in the walls of blood vessels and increasing blood flow to specific areas of the body. In the case of ED, it increases blood flow to the penis during sexual stimulation. In PAH, it relaxes blood vessels in the lungs, lowering pulmonary blood pressure and improving exercise capacity. It can also relax muscles in the prostate and bladder, improving BPH symptoms.
Dosage:
- Erectile Dysfunction (ED):
- As needed: The typical starting dose is 100mg, taken before sexual activity. The dose can be increased to 200mg based on effectiveness and tolerability. The maximum recommended dose is 20mg once daily.
- Once daily: For frequent sexual activity, a lower dose of 2.5mg or 5mg may be taken once daily.
- Benign Prostatic Hyperplasia (BPH): The usual dose is 200mg once daily.
- Pulmonary Arterial Hypertension (PAH): The typical dose is 100mg (two 20mg tablets) once daily.
A 200mg dose of tadalafil is significantly higher than the typical maximum doses and could carry a higher risk of side effects.
Precautions and Side Effects (General for Tadalafil):
It is crucial to be aware of the precautions and potential side effects associated with tadalafil:
- Contraindications: Do not take tadalafil if you are also using nitrate medications for chest pain or guanylate cyclase stimulators for pulmonary hypertension.
- Cardiovascular Risks: Sexual activity carries a risk for individuals with heart conditions, and tadalafil can interact with certain heart medications.
- Priapism: A rare but serious side effect is a prolonged and painful erection lasting more than 4 hours, which requires immediate medical attention.
- Vision and Hearing Loss: Sudden vision or hearing loss has been reported rarely with PDE5 inhibitors, including tadalafil.
- Drug Interactions: Tadalafil can interact with other medications, including alpha-blockers, certain antifungals, and antibiotics.
- Common Side Effects: Headache, flushing, upset stomach, muscle pain, back pain, and nasal congestion are possible.
Never take medication, especially at a high dose, without clear instructions and supervision from a qualified healthcare professional. They can provide accurate information based on your specific medical condition and other medications you may be taking.
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